Former 2020 presidential candidate and South Bend, Indiana, Mayor Pete Buttigieg has made history as the primary openly gay Cabinet member in U.S. history to be confirmed by the Senate.

At age 39, Buttigieg additionally represents one other “first” as a millennial and the youngest particular person nominated to Biden’s Cabinet.

Arizona Sen. Kyrsten Sinema, the nation’s first openly bisexual senator, was presiding over the Senate Tuesday and introduced the 86-13 last vote.

He will assume a division with 55,000 staff and a finances of tens of billions of {dollars}.

Buttigieg tweeted shortly after the affirmation vote that he is “honored and humbled” and “ready to get to work.”

In a speech from Wilmington, Delaware, Buttigieg mirrored on what the second means for all LGBTQ Americans when Biden introduced his nomination late final yr.

“I can remember watching the news — 17-years-old in Indiana, seeing a story about an appointee of President Clinton named to be an ambassador attacked and denied a vote in the Senate because he was gay — ultimately able to serve only by a recess appointment,” he mentioned. “And I learned something about some of the limits that exist in this country when it comes to who is allowed to belong. But just as important, I saw how those limits could be challenged.”

Buttigieg was referring to the nomination of James Hormel to be ambassador to Luxembourg underneath then-President Bill Clinton in 1998. Senate Republicans held up the nomination in protest for 2 years till Clinton made the appointment himself, with out affirmation, whereas the Senate was in recess. He related the reminiscence to his personal affirmation listening to final month in an interview with ABC’s “The View.”

“As I was in that hearing taking those questions from senators, you could see my husband, Chasten, over my shoulder, and that is something that has never happened before for a Cabinet nominee,” Buttigieg mentioned. “My hope is that, in turn, makes it easier for the next person to come along, so that this is never even viewed as a barrier by a future generation.”

During his listening to, some Republican senators pressed Buttigieg on the price of Biden’s infrastructure plan, which redirects cash for inexperienced initiatives, earlier than he cleared the Senate Commerce Committee with a 21-3 vote final month.

Following his fast ascent in the course of the 2020 main, the rising star within the Democratic Party was the one formal rival Biden picked to affix his administration after he introduced Vice President Kamala Harris as his operating mate in August.

Biden spoke extremely of Buttigieg following the previous mayor’s endorsement, saying he reminded Biden of his late son, Beau.

“I don’t think I’ve ever done this before, but he reminds me of my son Beau. And I know to — that may not mean much to most people, but to me, it’s the highest compliment I can give any man or woman,” Biden mentioned of Buttigieg final March.

Though Buttigieg would push ahead Biden’s transportation initiatives, together with an formidable infrastructure plan, the previous mayor launched his personal $1 trillion infrastructure plan final yr that included enhancements to a variety of the nation’s transportation infrastructure. Its detailed plans to provide extra energy to native communities, known as for upgrades to roads and public transportation and in addition highlighted street security with a nationwide Vision Zero purpose.

LGBTQ rights organizations have praised Buttigieg’s nomination as a serious step in guaranteeing the incoming administration displays the nation’s range.

Sarah Kate Ellis, president and CEO of GLAAD, the world’s largest LGBTQ media advocacy group, congratulated Buttigieg on his historic ascent on social media Tuesday as it grew to become clear the Senate would verify him.

“His historic confirmation hearing, where he introduced his husband Chasten, was also a milestone for LGBTQ acceptance and representation,” she mentioned. “Secretary Buttigieg’s vision will improve all Americans’ lives and navigate toward needed change to serve communities on the margins. We know he will continue to lead our country’s drive for LGBTQ acceptance.”

The former mayor got here out publicly in 2015 by way of an essay within the South Bend Tribune whereas searching for reelection. He was elected with 80% of the vote, greater than he acquired throughout his earlier election. He served within the position from 2012 to 2018.

Other presidential administrations have featured high-ranking LGBTQ officers. Eric Fanning served as Secretary of the Army in the course of the Obama Administration, the primary openly gay particular person to carry an armed service’s prime civilian place. In the Trump administration, Richard Grenell served as appearing director of National Intelligence, the primary openly gay particular person to serve in a Cabinet-level place in an appearing capability, however his place was not Senate-confirmed.

Biden’s Cabinet additionally contains the primary feminine treasury secretary, first feminine director of National Intelligence and first Black protection secretary.

Buttigieg is the fifth Cabinet degree official of Biden’s to be confirmed by the Senate.

ABC News’ Molly Nagle, Justin Gomez, Sarah Kolinovsky and Allison Pecorin contributed to this report.